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Pharmacology · single question

What is the mechanism of action of Amlodipine?

  1. Increase cardiac output
  2. Reduce cardiac workload
  3. Reduce cardiac compliance
  4. Block beta-adrenergic receptors
Show answer and explanation

Correct answer: B. Reduce cardiac workload

  • A. INCORRECT — Amlodipine can mildly increase cardiac output as a result of afterload reduction, but this is a secondary effect, not the primary mechanism.
  • B. CORRECT — Amlodipine is a dihydropyridine calcium channel blocker. It causes peripheral vasodilation, reducing systemic vascular resistance (afterload), which decreases cardiac workload. It also mildly reduces heart rate and myocardial oxygen demand.
  • C. INCORRECT — Reducing cardiac compliance would worsen cardiac function. Amlodipine does not reduce myocardial compliance.
  • D. INCORRECT — Beta-blocker mechanism. Amlodipine blocks L-type calcium channels in vascular smooth muscle, not beta-adrenergic receptors.

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