Pharmacology · single question

What is the mechanism of action of omeprazole?

  1. H2-receptor antagonist
  2. Proton pump inhibitor (PPI)
  3. Antacid (acid neutralizer)
  4. Prokinetic agent
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Correct answer: B. Proton pump inhibitor (PPI)

  • A. H2 blockers (e.g., ranitidine) act on histamine receptors, not the proton pump.
  • B. Correct. Omeprazole irreversibly inhibits the H+/K+ ATPase (proton pump) of gastric parietal cells.
  • C. Antacids chemically neutralize existing acid; they don't inhibit secretion.
  • D. Prokinetics speed gastric emptying; unrelated mechanism.

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