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Pharmacology · single question

What is the mechanism of action of statins (e.g., simvastatin, atorvastatin)?

  1. Activation of LDL receptors directly
  2. Inhibition of cholesterol absorption in the gut
  3. Activation of PPAR-alpha
  4. Inhibition of HMG-CoA reductase
Show answer and explanation

Correct answer: D. Inhibition of HMG-CoA reductase

  • A. Statins indirectly upregulate LDL receptors as a downstream effect, but the primary MOA is enzyme inhibition.
  • B. Cholesterol absorption inhibition is the MOA of ezetimibe.
  • C. PPAR-alpha activation is the MOA of fibrates (gemfibrozil, fenofibrate).
  • D. Correct. Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis, reducing LDL-C levels.

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