Pharmacology · single question

Which medication is LEAST likely to cause xerostomia (dry mouth)?

  1. Amitriptyline
  2. Hydrochlorothiazide
  3. Diphenhydramine
  4. Acetaminophen
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Correct answer: D. Acetaminophen

  • A. Amitriptyline (a tricyclic antidepressant) has strong anticholinergic effects and is a classic cause of xerostomia.
  • B. Hydrochlorothiazide (a diuretic) commonly causes dry mouth via fluid loss.
  • C. Diphenhydramine (an antihistamine) has anticholinergic properties and commonly causes xerostomia.
  • D. Correct. Acetaminophen has no significant anticholinergic or diuretic properties and is not associated with xerostomia, making it the least likely to cause dry mouth among these options.

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