Pharmacology · single question
What is the mechanism of action of nitroglycerin?
Show answer and explanation
Correct answer: A. Releases nitric oxide → vasodilation of coronary arteries
Nitroglycerin is metabolized to nitric oxide (NO), which activates guanylate cyclase → increases cGMP → smooth muscle relaxation → vasodilation of coronary arteries, reducing cardiac preload and relieving angina. It does NOT block calcium channels (that's CCBs) or beta receptors (beta-blockers) or sodium channels.