Which of the following medications can cause xerostomia, thereby increasing the risk of cervical caries?

All three medications have been associated with xerostomia (dry mouth): Hydrochlorothiazide (a thiazide diuretic) is well-documented to cause dry mouth through diuresis and fluid depletion. Rosuvastatin (a statin) has been reported to cause xerostomia, though the mechanism is less clear. Metformin can reduce salivary flow in some patients. Xerostomia from any cause increases caries risk, particularly cervical (root) caries, because saliva's buffering, remineralizing, and cleansing functions are compromised. Dentists should be aware of all xerogenic medications in a patient's regimen.