Pharmacology · single question
What is the mechanism of action of local anesthetics?
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Correct answer: A. Blockade of voltage-gated sodium channels in the nerve cell membrane, preventing depolarization and action potential propagation
Local anesthetics work by blocking voltage-gated sodium channels in the nerve cell membrane from the inside of the cell, preventing the influx of sodium ions needed for depolarization and thus preventing generation and propagation of action potentials along the nerve fiber.