Pharmacology · single question

CASE 13 — What medication should be prescribed for acute masticatory muscle spasm?

  1. Gabapentin
  2. Ibuprofen
  3. Cyclobenzaprine
  4. Carbamazepine
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Correct answer: C. Cyclobenzaprine

  • A. Gabapentin is used for neuropathic pain and epilepsy — not first-line for acute skeletal muscle spasm.
  • B. Ibuprofen (NSAID) addresses inflammation and mild pain but does not specifically relax muscle spasm.
  • C. Cyclobenzaprine (Flexeril) is a centrally-acting skeletal muscle relaxant and is the drug of choice for acute masticatory muscle spasm in dentistry. It reduces muscle hyperactivity and is used short-term (2–3 weeks).
  • D. Carbamazepine is an anticonvulsant specifically indicated for trigeminal neuralgia — not first-line for acute muscle spasm.

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