Pharmacology · single question

What is the mechanism of action of apixaban?

  1. Direct factor Xa inhibition
  2. Direct thrombin (factor IIa) inhibition
  3. Vitamin K antagonism
  4. Antithrombin III potentiation
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Correct answer: A. Direct factor Xa inhibition

  • A. Correct. Apixaban (and rivaroxaban, edoxaban) directly inhibit factor Xa. Unlike warfarin, there is no INR to monitor — bleeding risk is managed by timing rather than laboratory titration.
  • B. That is dabigatran, the direct thrombin inhibitor.
  • C. That is warfarin, which inhibits vitamin K epoxide reductase.
  • D. That is heparin, which potentiates antithrombin III.

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