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Pharmacology · single question

What is the mechanism of action of abacavir?

  1. Protease inhibitor
  2. Integrase strand transfer inhibitor
  3. Nucleoside reverse transcriptase inhibitor
  4. CCR5 antagonist
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Correct answer: C. Nucleoside reverse transcriptase inhibitor

  • A. Protease inhibitors are the '-navir' drugs (ritonavir, atazanavir).
  • B. Integrase inhibitors are the '-tegravir' drugs (dolutegravir, raltegravir).
  • C. Correct. Abacavir is an NRTI. Clinically important: HLA-B*5701 carriers can develop a severe hypersensitivity reaction, so genetic screening is required before prescribing.
  • D. Maraviroc is the CCR5 antagonist.

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