Pharmacology · single question

What is the mechanism of action of a chemical sanitizer/disinfectant such as glutaraldehyde?

  1. Denaturation of proteins
  2. Inhibition of DNA gyrase
  3. Disruption of the ribosome
  4. Chelation of metals
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Correct answer: A. Denaturation of proteins

  • A. Correct. Sanitizers/disinfectants (and moist-heat sterilization) kill microbes largely by denaturing/coagulating proteins.
  • B. DNA gyrase inhibition is the action of fluoroquinolone antibiotics, not chemical disinfectants.
  • C. Ribosomal disruption describes certain antibiotics, not surface disinfectants.
  • D. Metal chelation (e.g., EDTA) is not the disinfectant mechanism.

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