Pharmacology · single question

What is a recognized side effect of hydrochlorothiazide?

  1. Hyperkalemia
  2. Hypokalemia, hyperglycemia, and hyperuricemia (can precipitate gout)
  3. Bradycardia
  4. Hepatotoxicity
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Correct answer: B. Hypokalemia, hyperglycemia, and hyperuricemia (can precipitate gout)

Thiazide diuretics like HCTZ classically cause hypokalemia (via increased distal K+ secretion), can worsen glucose tolerance (hyperglycemia), and raise uric acid levels (hyperuricemia), which can precipitate or worsen gout.

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