Pharmacology · single question

What is the mechanism of action of rosuvastatin?

  1. Bile acid sequestrant
  2. HMG-CoA reductase inhibitor
  3. Fibrate (PPAR-alpha agonist)
  4. PCSK9 inhibitor
Show answer and explanation

Correct answer: B. HMG-CoA reductase inhibitor

  • A. Bile acid sequestrants (e.g., cholestyramine) act in the gut, not on cholesterol synthesis.
  • B. Correct. Statins inhibit HMG-CoA reductase, reducing hepatic cholesterol synthesis.
  • C. Fibrates mainly lower triglycerides via a different pathway.
  • D. PCSK9 inhibitors are injectable monoclonals, not statins.

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