Pharmacology · single question
Amoxicillin will interact with all of the following EXCEPT:
Show answer and explanation
Correct answer: C. Analgesics
- A. Amoxicillin has a historically noted (though now controversial) interaction with oral contraceptives — traditionally advised to use backup contraception.
- B. Amoxicillin DOES interact with methotrexate — it reduces renal tubular excretion of methotrexate, increasing its toxicity.
- C. Amoxicillin does NOT have a clinically significant interaction with standard analgesics (acetaminophen, NSAIDs). Analgesics are the EXCEPTION. Known amoxicillin interactions include: warfarin (bleeding risk), methotrexate (toxicity), oral contraceptives (may reduce efficacy), and other antibiotics.
- D. Amoxicillin DOES interact with warfarin — it may increase anticoagulant effect by reducing vitamin K production by gut bacteria, increasing bleeding risk.