Pharmacology · single question
What happens to most drugs when they are metabolized (biotransformed) in the liver?
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Correct answer: C. Their water (hydro) solubility is increased, facilitating renal excretion
Hepatic metabolism (Phase I oxidation/reduction and especially Phase II conjugation) generally converts lipophilic drugs into more polar, water-soluble metabolites so the kidneys can excrete them. Most metabolites are less active, though some drugs form active metabolites (see the diazepam question below).