Pharmacology · single question

Tardive dyskinesia (involuntary facial movements) is most likely caused by which medication?

  1. Trazodone
  2. Phenelzine
  3. Clozapine
  4. Haloperidol
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Correct answer: D. Haloperidol

Haloperidol is a first-generation (typical) antipsychotic and a well-known cause of tardive dyskinesia u2014 repetitive involuntary facial/lingual movements from long-term dopamine receptor blockade. Clozapine is a second-generation antipsychotic with lower TD risk. SSRIs (trazodone) and MAOIs (phenelzine) do not cause TD.

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