Pharmacology · single question

Warfarin produces its anticoagulant effect by:

  1. Directly inhibiting thrombin
  2. Inhibiting synthesis of vitamin K–dependent clotting factors
  3. Activating antithrombin III
  4. Blocking the platelet ADP receptor
Show answer and explanation

Correct answer: B. Inhibiting synthesis of vitamin K–dependent clotting factors

  • A. Direct thrombin inhibition describes dabigatran.
  • B. Correct. Warfarin blocks vitamin-K epoxide reductase, reducing factors II, VII, IX, X.
  • C. Antithrombin activation describes heparin.
  • D. ADP-receptor blockade describes clopidogrel.

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