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Medical Emergencies · single question

Von Willebrand Disease Type 2 is characterized by which kind of defect?

  1. Deficiency of Factor VIII only
  2. Complete absence of vWF
  3. Quantitative deficiency (reduced amount) of vWF
  4. Qualitative defect (abnormal function) of vWF
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Correct answer: D. Qualitative defect (abnormal function) of vWF

  • A. Incorrect. Factor VIII deficiency alone describes Hemophilia A. In vWD, Factor VIII may also be low (because vWF carries/protects Factor VIII), but the primary defect is in vWF itself.
  • B. Incorrect. Complete absence of vWF is Type 3 vWD (the most severe form, autosomal recessive).
  • C. Incorrect. Quantitative deficiency of vWF (reduced amount but normal function) is Type 1 vWD.
  • D. Correct. Type 2 vWD is characterized by a QUALITATIVE DEFECT — the vWF is produced in normal or near-normal amounts but has ABNORMAL FUNCTION (e.g., defective platelet binding, abnormal multimer structure). There are four subtypes (2A, 2B, 2M, 2N) each with different functional abnormalities.

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