How do you treat hives (urticaria)?

HIVES (urticaria) — mild/moderate: First-line treatment is ANTIHISTAMINES (H1 blockers) such as diphenhydramine, cetirizine, or loratadine. Topical steroids (A) are not very effective for systemic urticaria. IV antibiotics (C) are for bacterial infections. Epinephrine (D) is reserved for ANAPHYLAXIS with systemic involvement (hypotension, airway compromise) — not for simple hives alone. Oral antihistamines ± oral corticosteroids are standard for urticaria. B is correct.