Pathology · single question
The radiographic pattern in SICKLE CELL ANEMIA is primarily due to:
Show answer and explanation
Correct answer: D. Bone marrow hyperplasia from compensatory erythropoiesis
In sickle cell anemia, the bone marrow compensates for hemolytic anemia through hyperplasia — expanding marrow spaces and causing characteristic radiographic changes: 'hair on end' trabecular pattern (skull), step-ladder pattern (vertebrae), and coarse trabecular pattern with wide medullary spaces in the jaws. This is from marrow hyperplasia, not necrosis.
- A. CORRECT. Bone marrow hyperplasia from chronic hemolytic anemia causes expansion of marrow spaces and characteristic trabecular patterns.
- B. Partially correct but incomplete. Avascular necrosis can occur but is not the primary cause of the characteristic radiographic pattern.
- C. Incorrect. Osteosarcoma is not associated with sickle cell anemia.
- D. Incorrect. Calcium deposition would cause radiopaque changes — sickle cell changes are trabecular/lucent patterns.