Medical Emergencies · single question

The Pfizer-BioNTech COVID-19 vaccine works by which mechanism?

  1. It contains a live SARS-CoV-2 virus
  2. It contains a live attenuated virus
  3. mRNA instructs cells to produce the SARS-CoV-2 spike protein, triggering immunity
  4. It delivers a replicating viral protein
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Correct answer: C. mRNA instructs cells to produce the SARS-CoV-2 spike protein, triggering immunity

  • A. It is not a live-virus vaccine; no whole virus is present.
  • B. It is not a live attenuated vaccine.
  • C. Correct. Pfizer-BioNTech is an mRNA vaccine. The mRNA codes for the spike (S) protein; host cells translate it, the immune system recognizes the spike, and protective antibodies/T-cells develop.
  • D. The vaccine does not contain a self-replicating protein; it delivers mRNA encoding the spike protein.

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