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Pharmacology · single question

The maximum dose of 4% articaine in a healthy adult is:

  1. 7 mg/kg
  2. 5 mg/kg
  3. 6 mg/kg
  4. 4.4 mg/kg
Show answer and explanation

Correct answer: A. 7 mg/kg

  • A. Correct. The maximum dose of articaine (4% solution) is 7 mg/kg with a maximum of 500 mg total. This is higher than lidocaine (4.4 mg/kg) because articaine is metabolized both by plasma esterases AND hepatic pathways, allowing for a higher safe dose.
  • B. 5 mg/kg is not the correct maximum for articaine.
  • C. 6 mg/kg is not the accepted maximum dose for articaine.
  • D. 4.4 mg/kg is the maximum dose for LIDOCAINE (2%), not articaine.

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