Pharmacology · single question
The antiplatelet/anti-inflammatory action of aspirin is due to:
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Correct answer: A. Irreversible inhibition of cyclooxygenase (COX-1), blocking thromboxane A2 synthesis
- A. Correct. Aspirin irreversibly acetylates COX, preventing thromboxane A2 formation in platelets for their lifespan (~7-10 days).
- B. Aspirin's platelet effect is irreversible, not reversible, and not COX-2-selective.
- C. Vitamin K antagonism describes warfarin.
- D. Direct factor Xa inhibition describes apixaban/rivaroxaban.