Micro & Immunology · single question

T-helper cells recruit cytotoxic T-cells primarily through which interleukin?

  1. IL-1
  2. IL-2
  3. IL-3
  4. IL-4
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Correct answer: B. IL-2

Interleukin-2 (IL-2) is the primary cytokine secreted by activated T-helper cells (CD4+) that promotes the proliferation and activation of cytotoxic T-cells (CD8+). IL-2 is also an autocrine growth factor for T-helper cells themselves. IL-1 is produced primarily by macrophages and activates T-helper cells. IL-3 stimulates hematopoietic progenitor cells. IL-4 promotes B-cell differentiation and IgE production. IL-2 is the central mediator linking T-helper cell activation to cytotoxic T-cell recruitment.

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