Micro & Immunology · single question
Systemic Lupus Erythematosus (SLE) is primarily mediated by which type of hypersensitivity?
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Correct answer: C. Type III (immune complex)
✓ C) Type III (immune complex) hypersensitivity is correct.
SLE is a classic Type III hypersensitivity disease: antinuclear antibodies (ANA, anti-dsDNA) form immune complexes that deposit in tissues (kidneys, skin, joints, vessels), activating complement and causing inflammation. The butterfly rash, glomerulonephritis, and vasculitis are immune complex-mediated. Oral manifestations: discoid lupus lesions resembling lichen planus. Type I = allergies/anaphylaxis. Type II = hemolytic anemia, pemphigus. Type IV = contact dermatitis, TB reaction.
SLE is a classic Type III hypersensitivity disease: antinuclear antibodies (ANA, anti-dsDNA) form immune complexes that deposit in tissues (kidneys, skin, joints, vessels), activating complement and causing inflammation. The butterfly rash, glomerulonephritis, and vasculitis are immune complex-mediated. Oral manifestations: discoid lupus lesions resembling lichen planus. Type I = allergies/anaphylaxis. Type II = hemolytic anemia, pemphigus. Type IV = contact dermatitis, TB reaction.
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