Micro & Immunology · single question
Systemic lupus erythematosus is mediated primarily by which hypersensitivity type?
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Correct answer: A. Type III (immune-complex)
- A. Correct. SLE is a prototypical type III (immune-complex) hypersensitivity — antigen–antibody complexes deposit in tissues and activate complement.
- B. Type I (IgE-mediated) underlies anaphylaxis and allergies.
- C. Type II involves antibodies against cell-surface antigens (e.g., autoimmune hemolytic anemia).
- D. Type IV is delayed, T-cell mediated (e.g., contact dermatitis, TB skin test).
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