Medical Emergencies · single question

Same patient. Which laboratory value would be most significantly altered due to HIV infection?

  1. CD4 on neutrophils
  2. CD8 on neutrophils
  3. CD4 on T cells
  4. CD8 on T cells
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Correct answer: C. CD4 on T cells

  • A. Neutrophils do not carry CD4 as their defining marker — this is not the relevant value.
  • B. CD8 is not a neutrophil marker either.
  • C. Correct. HIV selectively infects and depletes CD4+ T-helper lymphocytes; the falling CD4 T-cell count is the key marker of disease progression.
  • D. CD8+ T cells are not the cells preferentially destroyed; the CD4 count (and CD4:CD8 ratio) is what drops.

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