Medical Emergencies · single question

Janeway lesions on the palms and soles are a sign of which condition?

  1. Kawasaki disease
  2. Systemic lupus erythematosus
  3. Rheumatic fever
  4. Infective endocarditis
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Correct answer: D. Infective endocarditis

  • A. Incorrect. Kawasaki disease causes diffuse palmar erythema with later desquamation, in a child with prolonged fever.
  • B. Incorrect. SLE produces a malar butterfly rash and discoid lesions, not palmar septic emboli.
  • C. Incorrect. Rheumatic fever produces erythema marginatum and subcutaneous nodules.
  • D. Correct. Janeway lesions are non-tender haemorrhagic macules on the palms and soles caused by septic microemboli — a peripheral stigma of infective endocarditis, alongside Osler nodes, splinter haemorrhages and Roth spots.

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