Pathology · single question
Pemphigus vulgaris — suprabasilar split and Tzanck (acantholytic) cells.
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Correct answer: D. Pemphigus vulgaris
Pemphigus vulgaris is characterized by INTRA-epithelial (suprabasilar) splits due to autoantibodies against desmoglein 3 (and 1), producing acantholysis ("row of tombstones" basal cells). Mucous membrane pemphigoid is SUB-epithelial (basement membrane antibodies to BP180/laminin), producing a deeper split and more stable blisters.