Pharmacology · single question
Mechanism of action of bisphosphonates?
Show answer and explanation
Correct answer: A. Inhibit osteoclasts
- A. Correct. Bisphosphonates bind hydroxyapatite and are ingested by osteoclasts, inducing osteoclast apoptosis/inhibition, thereby decreasing bone resorption.
- B. Bisphosphonates act on osteoclasts, not by directly stimulating osteoblast activity.
- C. RANKL inhibition is the mechanism of denosumab (a monoclonal antibody), not bisphosphonates.
- D. This is unrelated to the bisphosphonate mechanism.