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Pharmacology · single question

Local anesthetics block nerve conduction by __________________.

  1. Depolarizing the nerve membrane
  2. Increasing membrane permeability to Ku207a
  3. Increasing membrane permeability to Nau207a
  4. Preventing an increase in membrane permeability to Ku207a
  5. Preventing an increase in membrane permeability to Nau207a
Show answer and explanation

Correct answer: E. Preventing an increase in membrane permeability to Nau207a

Local anesthetics are sodium channel blockers. They bind voltage-gated Nau207a channels and prevent Nau207a influx during depolarization, blocking action potential propagation and eliminating pain signal transmission.

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