Pharmacology · single question

Lithium toxicity is most associated with which complication?

  1. Nephrotoxicity / renal impairment (with neurologic toxicity)
  2. Hepatic cirrhosis
  3. Pulmonary fibrosis
  4. Hemolytic anemia
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Correct answer: A. Nephrotoxicity / renal impairment (with neurologic toxicity)

  • A. Correct. Lithium is cleared by the kidneys and is nephrotoxic; toxicity also causes tremor, ataxia, and seizures. NSAIDs raise lithium levels — a key dental prescribing caution.
  • B. Incorrect. Cirrhosis is not a characteristic lithium effect.
  • C. Incorrect. Pulmonary fibrosis is linked to other drugs (e.g., amiodarone, bleomycin), not lithium.
  • D. Incorrect. Hemolytic anemia is not a typical lithium toxicity.

Note: The source listed 'cardiac/kidney attack' as distractors; renal toxicity is the established answer.

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