Micro & Immunology · single question
Interferon-gamma (IFN-γ) stimulates B cells to produce which immunoglobulin?
Show answer and explanation
Correct answer: A. IgG
- A. Correct. IFN-γ (produced by Th1 cells) drives class switching to IgG — specifically IgG1 and IgG3 in humans. IFN-γ promotes opsonizing and complement-fixing IgG subclasses, enhancing phagocytosis-mediated immunity.
- B. Incorrect. IgE production is driven by IL-4 and IL-13 (in Th2-mediated responses) — IFN-γ actually SUPPRESSES IgE production.
- C. Incorrect. IgM is the first antibody produced in a primary immune response — its class switching is driven by different cytokines.
- D. Incorrect. IgA production is primarily stimulated by IL-5 and TGF-β (in mucosal tissues) — not IFN-γ.
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