In the PICO framework for clinical questions, what does the letter 'I' stand for?

PICO is a structured format for formulating evidence-based clinical questions: P = Patient/Population/Problem, I = Intervention (the treatment, test, or exposure being evaluated), C = Comparison (the control or alternative intervention), O = Outcome (what you are measuring). Using the PICO framework helps clinicians search the literature efficiently and critically appraise evidence. In some contexts, PICO is expanded to PICOT where T = Time.