Histopathology describes giant cells. Which differential diagnosis is most related?

Correct answer: A. Brown's tumor (hyperparathyroidism)

• A. Correct. Brown's tumor (associated with hyperparathyroidism) classically shows multinucleated giant cells histologically, similar in appearance to central giant cell granuloma and cherubism, and must be included in this differential.
• B. Squamous cell carcinoma shows malignant epithelial cells, not multinucleated giant cells, on histology.
• C. Ameloblastoma shows odontogenic epithelial islands, not giant cells, on histology.
• D. Pleomorphic adenoma shows mixed epithelial/myoepithelial and stromal elements, not giant cells.