Pathology · patient case question

Given the multilocular soap-bubble appearance with cortical expansion in the posterior mandible, which diagnosis is most likely?

Patient case: Cortical Expansion of the Posterior Mandible

demo: 34-year-old male

chief: “The outside of my jaw has been slowly swelling for about a year.”

history: Non-contributory. No pain, no paresthesia.

meds: None

findings: Occlusal radiograph shows buccal and lingual cortical expansion in the posterior mandible. Panoramic view shows a multilocular soap-bubble radiolucency. Clinical images and radiographs shown below.

  1. Simple bone cyst
  2. Condensing osteitis
  3. Ameloblastoma
  4. Periapical cemento-osseous dysplasia
Show answer and explanation

Correct answer: C. Ameloblastoma

  • A. A simple bone cyst produces a scalloped radiolucency between roots without expansion and with no lining.
  • B. Condensing osteitis is radiopaque, not radiolucent.
  • C. Correct. Ameloblastoma is a benign but locally aggressive odontogenic tumor with a strong predilection for the posterior mandible, producing multilocular soap-bubble or honeycomb radiolucency with marked cortical expansion and often root resorption.
  • D. Cemento-osseous dysplasia is a periapical mixed-density lesion of vital anterior mandibular teeth, without expansion.

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