Pharmacology · single question

Diphenhydramine (Benadryl), a first-generation antihistamine, commonly causes which oral side effect?

  1. Xerostomia (dry mouth)
  2. Excessive salivation
  3. Gingival overgrowth
  4. Black hairy tongue
Show answer and explanation

Correct answer: A. Xerostomia (dry mouth)

  • A. Correct. Its anticholinergic activity reduces salivary flow, causing dry mouth.
  • B. It decreases—not increases—salivation.
  • C. Gingival overgrowth is linked to phenytoin, cyclosporine, and CCBs, not antihistamines.
  • D. Black hairy tongue is associated with tobacco/antibiotics/poor hygiene.

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