Pharmacology · single question
Denosumab exerts its antiresorptive effect by:
Show answer and explanation
Correct answer: B. Binding and inhibiting RANK ligand (RANKL)
Denosumab is a monoclonal antibody that binds RANKL, preventing its interaction with RANK on osteoclast precursors. This inhibits osteoclast differentiation, activation, and survival. Unlike bisphosphonates, denosumab does NOT incorporate into bone — its effect wears off in ~6 months after discontinuation. Both drugs elevate the risk of MRONJ, especially with invasive dental procedures.