Pharmacology · single question
Bupropion is used for which of the following conditions?
Show answer and explanation
Correct answer: C. Both smoking cessation AND depression
Both smoking cessation AND depression (C) — but looking at the answer choices as presented in the original exam, the answer is Smoking cessation (A) as the dental-board relevant use. However, bupropion is FDA-approved for BOTH:
• Major Depressive Disorder (brand: Wellbutrin)
• Smoking cessation (brand: Zyban)
• Mechanism: Norepinephrine-Dopamine Reuptake Inhibitor (NDRI). Also a nicotinic acetylcholine receptor antagonist (contributes to smoking cessation).
• Dental relevance: Xerostomia is the key side effect.
• Contraindication: seizure disorders (lowers seizure threshold), eating disorders (bulimia/anorexia nervosa), abrupt alcohol/benzodiazepine withdrawal.
• Does NOT cause sexual dysfunction (unlike SSRIs) — often chosen for this reason.
• Major Depressive Disorder (brand: Wellbutrin)
• Smoking cessation (brand: Zyban)
• Mechanism: Norepinephrine-Dopamine Reuptake Inhibitor (NDRI). Also a nicotinic acetylcholine receptor antagonist (contributes to smoking cessation).
• Dental relevance: Xerostomia is the key side effect.
• Contraindication: seizure disorders (lowers seizure threshold), eating disorders (bulimia/anorexia nervosa), abrupt alcohol/benzodiazepine withdrawal.
• Does NOT cause sexual dysfunction (unlike SSRIs) — often chosen for this reason.