Pharmacology · single question

Amlodipine lowers blood pressure primarily by:

  1. Blocking L-type calcium channels, causing arterial vasodilation
  2. Blocking beta-1 adrenergic receptors
  3. Inhibiting ACE
  4. Promoting diuresis at the loop of Henle
Show answer and explanation

Correct answer: A. Blocking L-type calcium channels, causing arterial vasodilation

  • A. Correct. Amlodipine is a dihydropyridine calcium-channel blocker that relaxes vascular smooth muscle, producing arterial vasodilation and reduced peripheral resistance.
  • B. Beta-blockers act on cardiac beta receptors—different class.
  • C. ACE inhibitors block angiotensin conversion—different mechanism.
  • D. Loop diuretics act on the kidney, not vascular calcium channels.

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