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Pathology · single question

All of the following are features of ectodermal dysplasia EXCEPT:

  1. Dry skin (hypohidrosis)
  2. Brittle/sparse hair
  3. More common in males than females
  4. Y-linked inheritance (the classic hypohidrotic form is actually X-linked, not Y-linked)
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Correct answer: D. Y-linked inheritance (the classic hypohidrotic form is actually X-linked, not Y-linked)

The classic hypohidrotic form of ectodermal dysplasia follows X-LINKED recessive inheritance, which is exactly why it's more common and more severe in males (who have only one X chromosome) than in females (who are typically carriers). 'Y-linked' is incorrect and is the exception — periorbital fine wrinkling, dry skin, and brittle/sparse hair are all genuinely recognized features.

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