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Pathology · single question

Cherubism is most accurately classified as which type of condition?

  1. A hereditary (genetic) fibro-osseous condition, caused by autosomal dominant SH3BP2 gene mutations
  2. A purely reactive lesion with no genetic basis
  3. An infectious condition
  4. A purely traumatic/iatrogenic condition
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Correct answer: A. A hereditary (genetic) fibro-osseous condition, caused by autosomal dominant SH3BP2 gene mutations

Cherubism is a hereditary, autosomal dominant fibro-osseous condition caused by SH3BP2 gene mutations, producing bilateral, symmetric, multilocular jaw lesions in children that often stabilize or regress after puberty. While it's sometimes grouped under broader 'developmental fibro-osseous lesions' classification schemes in some textbooks, its well-documented specific genetic transmission pattern makes 'hereditary' the most precise classification.

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