Pathology · single question

A patient presents with firm nodular growths on the lingual surface of the mandible, consistent with tori (exostosis). If a biopsy were performed on this lesion, what would be seen microscopically?

  1. Hyperkeratosis with dysplastic epithelial cells
  2. Normal mucosa overlying normal bone
  3. Inflammatory infiltrate with osteoclastic activity
  4. Calcification within fibrous connective tissue
Show answer and explanation

Correct answer: B. Normal mucosa overlying normal bone

  • A. Dysplastic epithelial cells are characteristic of premalignant lesions such as leukoplakia or carcinoma in situ — not tori/exostoses, which are benign bony protuberances with no epithelial dysplasia.
  • B. CORRECT. Exostoses (including tori) are benign focal overgrowths of cortical bone. Histologically, biopsy shows normal overlying mucosa (non-dysplastic stratified squamous epithelium) with normal underlying compact bone — no dysplasia, no inflammation, no unusual cellular activity. This benign appearance confirms the diagnosis.
  • C. Inflammatory infiltrate with osteoclastic activity suggests active bone destruction seen in infections, osteonecrosis, or aggressive bone lesions — not present in benign exostoses.
  • D. Calcification within fibrous connective tissue is characteristic of fibro-osseous lesions such as fibrous dysplasia or cemento-ossifying fibroma, not simple exostoses.

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