Pathology · single question
A pipe-smoker presents with redness and inflammation of the hard palate, with multiple elevated white papular lesions, each with a red central dot representing inflamed minor salivary gland duct orifices. What is the most likely diagnosis?
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Correct answer: A. Nicotinic stomatitis
Nicotinic stomatitis (smoker's palate) is a benign, chronic condition caused by heat from tobacco smoke, most commonly pipe smoking and cigar smoking. It characteristically presents on the hard palate as a white, keratinized background with multiple white papular elevations, each containing a red central dot representing the inflamed and metaplastic duct orifice of a minor salivary gland. This distinctive 'cobblestone' appearance is pathognomonic. Despite its alarming appearance, nicotinic stomatitis itself has a low malignant transformation potential. However, it signals heavy tobacco use, which is a strong risk factor for oral squamous cell carcinoma elsewhere in the mouth. The lesion typically resolves upon cessation of smoking.