Pathology · single question

A pipe-smoker presents with redness and inflammation of the hard palate, with multiple elevated white papular lesions, each with a red central dot representing inflamed minor salivary gland duct orifices. What is the most likely diagnosis?

  1. Nicotinic stomatitis
  2. Oral candidiasis
  3. Lichen planus
  4. Erythroleukoplakia
Show answer and explanation

Correct answer: A. Nicotinic stomatitis

Nicotinic stomatitis (smoker's palate) is a benign, chronic condition caused by heat from tobacco smoke, most commonly pipe smoking and cigar smoking. It characteristically presents on the hard palate as a white, keratinized background with multiple white papular elevations, each containing a red central dot representing the inflamed and metaplastic duct orifice of a minor salivary gland. This distinctive 'cobblestone' appearance is pathognomonic. Despite its alarming appearance, nicotinic stomatitis itself has a low malignant transformation potential. However, it signals heavy tobacco use, which is a strong risk factor for oral squamous cell carcinoma elsewhere in the mouth. The lesion typically resolves upon cessation of smoking.

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