A patient taking losartan (Cozaar) reports an unusual side effect. Which is the MOST recognized side effect specific to angiotensin receptor blockers (ARBs)?

Correct answer: D. Altered taste (dysgeusia)

• A. Angioedema can occur with ARBs but is much more commonly associated with ACE inhibitors. ARBs are actually often used as an alternative in patients who develop ACE inhibitor-related angioedema.
• B. Dry cough is the classic side effect of ACE INHIBITORS (e.g., lisinopril) due to bradykinin accumulation — ARBs do NOT block bradykinin breakdown, so cough is rare with ARBs.
• C. Hyperkalemia can occur with both ACE inhibitors and ARBs (both reduce aldosterone), but it is not the most 'recognized specific side effect' of losartan.
• D. Correct. Dysgeusia (altered taste) is a recognized side effect of losartan specifically among ARBs. It is an important clinical consideration, especially in dentistry.