Pharmacology · single question

A patient taking antibiotics reports stomach upset/diarrhea. The most likely mechanism is:

  1. Disruption of the normal gastrointestinal flora
  2. Direct corrosion of the stomach lining by the drug
  3. An allergic (IgE) reaction
  4. Hypoglycemia from the antibiotic
Show answer and explanation

Correct answer: A. Disruption of the normal gastrointestinal flora

  • A. Correct. Broad-spectrum antibiotics disturb the normal GI microbiota, commonly producing nausea, cramping, and diarrhea (and in severe cases C. difficile colitis).
  • B. GI upset is from flora disruption/mucosal irritation, not literal corrosion of the lining.
  • C. An IgE allergic reaction would present with hives/anaphylaxis, not simple stomach upset.
  • D. Antibiotics do not cause hypoglycemia as the mechanism of GI upset.

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