Pharmacology · single question

The same patient is taking isoniazid for tuberculosis. What potential problem could he have?

  1. Hepatitis
  2. Nephrotoxicity
  3. Ototoxicity
  4. Hypertension
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Correct answer: A. Hepatitis

  • A. Correct. Isoniazid (and rifampin) are hepatotoxic; drug-induced hepatitis is a well-known adverse effect (isoniazid can also cause peripheral neuropathy, prevented with vitamin B6).
  • B. Nephrotoxicity is more typical of aminoglycosides, not isoniazid.
  • C. Ototoxicity is associated with aminoglycosides (e.g., streptomycin), not isoniazid.
  • D. Hypertension is not a characteristic isoniazid effect.

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