A patient takes methotrexate and adalimumab (Humira). Which laboratory test is most relevant before dental treatment?

Correct answer: A. Complete blood count with differential and renal/hepatic panel including creatinine

• A. Correct. Methotrexate causes myelosuppression and hepatotoxicity and is renally cleared; combined with a TNF-alpha inhibitor, the patient faces both infection risk from neutropenia and bleeding risk from thrombocytopenia.
• B. Thyroid function is unrelated to methotrexate or adalimumab therapy.
• C. Amylase assesses pancreatic and salivary gland function, not the risks of these drugs.
• D. Lipids are irrelevant to the immediate dental risks of these medications.