Pharmacology · single question

A patient takes hydrochlorothiazide and metformin. What conditions is this patient being treated for?

  1. Asthma and osteoporosis
  2. Heart failure and hypothyroidism
  3. Hypertension and type 2 diabetes mellitus
  4. Hyperlipidemia and gout
Show answer and explanation

Correct answer: C. Hypertension and type 2 diabetes mellitus

  • A. Incorrect. Asthma uses inhaled bronchodilators and corticosteroids; osteoporosis uses bisphosphonates.
  • B. Incorrect. Heart failure typically uses loop diuretics, ACE inhibitors and beta blockers; hypothyroidism uses levothyroxine.
  • C. Correct. Hydrochlorothiazide is a thiazide diuretic used for hypertension; metformin is a biguanide and first-line agent for type 2 diabetes. Dental relevance: xerostomia and orthostatic hypotension from the diuretic; hypoglycemia risk with the diabetes.
  • D. Incorrect. Hyperlipidemia uses statins; gout uses allopurinol or colchicine. Note that thiazides can actually PRECIPITATE gout by reducing uric acid excretion.

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