Pharmacology · single question

Which of the following benzodiazepines produces active metabolites?

  1. Lorazepam
  2. Diazepam
  3. Oxazepam
  4. Temazepam
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Correct answer: B. Diazepam

Among the benzodiazepines listed, diazepam is notable for producing active metabolites, the most important being desmethyldiazepam (nordiazepam) and oxazepam. These active metabolites prolong the drug's pharmacological effect and can accumulate, particularly in patients with hepatic impairment or in the elderly. The mnemonic 'LOT' (Lorazepam, Oxazepam, Temazepam) helps remember the benzodiazepines that do NOT produce clinically significant active metabolites and are therefore preferred in patients with liver disease or elderly patients. Diazepam is not in the LOT group, confirming it does produce active metabolites.

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